一些关于氯氮卓对金黄仓鼠（Mesocricetus auratus）社会互动影响的研究。
Some studies on the influence of chlordiazepoxide on the social interaction of golden hamsters (Mesocricetus auratus).
作者信息
Poole T B
出版信息
Br J Pharmacol. 1973 Jul;48(3):538-45. doi: 10.1111/j.1476-5381.1973.tb08360.x.
Abstract
- The effects of a ;minor' tranquillizer (chlordiazepoxide) on the social behaviour of male golden hamsters were investigated.2. Thirty-six hamsters were divided into pairs. Each pair was placed in an arena measuring 1 m(2); under these conditions the hamsters fought, but once a winner and loser emerged the relationship between the two animals became stabilized. The influence of 50 mg/kg chlordiazepoxide on this stable relationship was investigated and compared with normal behaviour in the arena.3. Under the influence of chlordiazepoxide, hamsters showed a significant reduction in ;aggression', ;defensive fighting' and an increase in ;investigation'.4. When the data for winners and losers were analysed independently, the drug was seen to influence losers more than winners.5. It is postulated that the primary influence of chlordiazepoxide is to reduce fear and as a result ;investigation' is probably affected indirectly as a behaviour pattern suppressed in an individual showing fear of its opponent.
摘要
研究了一种“轻度”镇静剂（氯氮卓）对雄性金黄仓鼠社会行为的影响。
36只仓鼠被分成 pairs。每对被放置在一个面积为1平方米的场地中；在这些条件下，仓鼠会打架，但一旦分出胜负，两只动物之间的关系就会稳定下来。研究了50毫克/千克氯氮卓对这种稳定关系的影响，并与场地中的正常行为进行了比较。
在氯氮卓的影响下，仓鼠的“攻击性”、“防御性打斗”显著减少，“探究行为”增加。
当对胜者和败者的数据进行独立分析时，发现药物对败者的影响大于胜者。
据推测，氯氮卓的主要作用是减轻恐惧，因此“探究行为”可能作为一种在对对手表现出恐惧的个体中被抑制的行为模式而受到间接影响。
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