用³H-¹⁴C-甲基标记的N-甲基-N-亚硝基脲对DNA进行甲基化——完整甲基基团转移的证据。 - Suppr

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Methylation of DNA by 3H-14C-methyl-labelled N-methyl-N-nitrosourea--evidence for transfer of the intact methyl group.

作者信息

Lawley P D, Shah S A

出版信息

Chem Biol Interact. 1973 Aug;7(2):115-20. doi: 10.1016/0009-2797(73)90020-3.

DOI:10.1016/0009-2797(73)90020-3

PMID:4797441

Abstract

摘要

相似文献

Methylation of DNA by 3H-14C-methyl-labelled N-methyl-N-nitrosourea--evidence for transfer of the intact methyl group.用³H-¹⁴C-甲基标记的N-甲基-N-亚硝基脲对DNA进行甲基化——完整甲基基团转移的证据。

Chem Biol Interact. 1973 Aug;7(2):115-20. doi: 10.1016/0009-2797(73)90020-3.

Reaction products from N-methyl-N-nitrosourea and deoxyribonucleic acid containing thymidine residues. Synthesis and identification of a new methylation product, O4-methylthymidine.N-甲基-N-亚硝基脲与含胸苷残基的脱氧核糖核酸的反应产物。一种新的甲基化产物O4-甲基胸苷的合成与鉴定。

Biochem J. 1973 Sep;135(1):193-201. doi: 10.1042/bj1350193.

Reaction of alkylating mutagens and carcinogens with nucleic acids: N-3 of guanine as a site of alkylation by N-methyl-N-nitrosourea and dimethyl sulphate.烷基化诱变剂和致癌物与核酸的反应：鸟嘌呤的N-3作为被N-甲基-N-亚硝基脲和硫酸二甲酯烷基化的位点。

Chem Biol Interact. 1972 May;4(6):431-4. doi: 10.1016/0009-2797(72)90064-6.

Methylation of ribonucleic acid by the carcinogens dimethyl sulphate, N-methyl-N-nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine. Comparisons of chemical analyses at the nucleoside and base levels.致癌物质硫酸二甲酯、N-甲基-N-亚硝基脲和N-甲基-N'-硝基-N-亚硝基胍对核糖核酸的甲基化作用。核苷和碱基水平化学分析的比较。

Biochem J. 1972 Jun;128(1):117-32. doi: 10.1042/bj1280117.

Reaction of N-n-butyl-N-nitrosourea with DNA in vitro.N-正丁基-N-亚硝基脲与DNA的体外反应。

Carcinogenesis. 1980;1(10):849-54. doi: 10.1093/carcin/1.10.849.

Methylation of DNA in various organs of C57B1 mice by a carcinogenic dose of N-methyl-N-nitrosourea and stabiltty of some methylation products up to 18 hours.致癌剂量的N-甲基-N-亚硝基脲对C57B1小鼠各器官DNA的甲基化作用以及某些甲基化产物长达18小时的稳定性。

Chem Biol Interact. 1975 Jun;10(6):413-27. doi: 10.1016/0009-2797(75)90072-1.

Rapid determination of methylated purines in DNA treated with N-methyl-N-nitrosourea using high-performance liquid chromatography.使用高效液相色谱法快速测定经N-甲基-N-亚硝基脲处理的DNA中的甲基化嘌呤。

Cancer Lett. 1979 May;6(6):311-7. doi: 10.1016/s0304-3835(79)80087-7.

Reaction of N-methyl-N-nitrosourea (MNUA) with 32P-labelled DNA: evidence for formation of phosphotriesters.N-甲基-N-亚硝基脲（MNUA）与32P标记的DNA的反应：磷酸三酯形成的证据。

Chem Biol Interact. 1973 Aug;7(2):127-30. doi: 10.1016/0009-2797(73)90022-7.

Identification of the methyl phosphotriester of thymidylyl (3',5')thymidine as a product from reaction of DNA with the carcinogen N-methyl-N-nitrosourea.鉴定胸苷酰（3'，5'）胸苷的甲基磷酸三酯为DNA与致癌物N-甲基-N-亚硝基脲反应的产物。

Chem Biol Interact. 1976 Sep;15(1):91-100. doi: 10.1016/0009-2797(76)90131-9.

Alkylation of rat brain nucleic acids by N-methyl-N-nitrosourea and methyl methanesulphonate.N-甲基-N-亚硝基脲和甲磺酸甲酯对大鼠脑核酸的烷基化作用。

J Neurochem. 1973 Feb;20(2):595-606. doi: 10.1111/j.1471-4159.1973.tb12158.x.

引用本文的文献

Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks.甲磺酸甲酯（MMS）会产生热不稳定的DNA损伤，但在体内未检测到DNA双链断裂。

Nucleic Acids Res. 2005 Jul 11;33(12):3799-811. doi: 10.1093/nar/gki681. Print 2005.

A system in mouse liver for the repair of O6-methylguanine lesions in methylated DNA.小鼠肝脏中用于修复甲基化DNA中O6-甲基鸟嘌呤损伤的系统。

Nucleic Acids Res. 1981 Jul 10;9(13):3089-103. doi: 10.1093/nar/9.13.3089.

Urinary excretion of methylated purines following inhalation of dimethyl sulphate.吸入硫酸二甲酯后甲基化嘌呤的尿排泄情况。

Experientia. 1974 Jun 15;30(6):641-2. doi: 10.1007/BF01921519.

Chemical carcinogenesis in the nervous system. Preferential accumulation of O6-methylguanine in rat brain deoxyribonucleic acid during repetitive administration of N-methyl-N-nitrosourea.神经系统中的化学致癌作用。重复给予N-甲基-N-亚硝基脲期间大鼠脑脱氧核糖核酸中O6-甲基鸟嘌呤的优先积累。

Biochem J. 1975 Jun;148(3):521-5. doi: 10.1042/bj1480521.

Properties of DNA modified with N-methyl-N-nitrosourea.

Radiat Environ Biophys. 1977 Oct 12;14(3):231-8. doi: 10.1007/BF01323941.

Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography.致癌物N-甲基-N-亚硝基脲、N-乙基-N-亚硝基脲和甲磺酸乙酯对C57BL小鼠各器官脱氧核糖核酸的体内烷基化作用与胸腺淋巴瘤诱导的关系。高压液相色谱法的一些应用。

Biochem J. 1978 Sep 15;174(3):1031-44. doi: 10.1042/bj1741031.

The effects of 1-methyl-1-nitrosourea on the survival pattern of cycling and noncycling HeLa cells.

J Cancer Res Clin Oncol. 1979 Jul 27;94(3):265-75. doi: 10.1007/BF00419286.

Isolation and identification of products from alkylation of nucleic acids: ethyl- and isopropyl-purines.核酸烷基化产物的分离与鉴定：乙基嘌呤和异丙基嘌呤

Biochem J. 1975 Jan;145(1):73-84. doi: 10.1042/bj1450073.

Apurinic acid endonuclease activity from mouse epidermal cells.来自小鼠表皮细胞的脱嘌呤酸内切酶活性。

Nucleic Acids Res. 1979 Jun 25;6(8):2901-17. doi: 10.1093/nar/6.8.2901.

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