肿瘤坏死血清可诱导出一群血清学上不同的自然杀伤细胞。
Tumor necrosis serum induces a serologically distinct population of NK cells.
作者信息
Chun M, Pasanen V, Hämmerling U, Hämmerling G F, Hoffmann M K
出版信息
J Exp Med. 1979 Sep 19;150(3):426-31. doi: 10.1084/jem.150.3.426.
Abstract
Murine spleen cells generate nonspecific cytotoxic cells, referred to as natural killer (NK) cells, within 4 d of incubation in Mishell-Dutton cultures. This NK cell type does not arise in cultures of BALB/c.nu spleen cells or in cultures of T-cell depleted C57BL/6 spleen cells, indicating that its activation depends on T cells. Another type of NK cells is induced by tumor necrosis serum in murine spleen-cell cultures. It arises within 24 h and its activation does not depend on T cells. This cell type (and its precursor) expresses the recently discovered cell-surface marker Qa5 (controlled by the Q region of chromosome 17) that distinguishes this NK cell from the NK cell that depends for its activation on thymic function. Qa5+ NK cells are also induced by interferon.
摘要
在米舍尔-达顿培养体系中培养4天后，小鼠脾细胞会产生非特异性细胞毒性细胞，即自然杀伤（NK）细胞。这种NK细胞类型不会在BALB/c.nu脾细胞培养物或T细胞耗竭的C57BL/6脾细胞培养物中出现，这表明其激活依赖于T细胞。另一种NK细胞类型是由肿瘤坏死血清在小鼠脾细胞培养物中诱导产生的。它在24小时内出现，其激活不依赖于T细胞。这种细胞类型（及其前体）表达最近发现的细胞表面标志物Qa5（由17号染色体的Q区域控制），该标志物将这种NK细胞与依赖胸腺功能激活的NK细胞区分开来。Qa5+ NK细胞也可由干扰素诱导产生。
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