白细胞介素2和白细胞介素3可增强自然杀伤细胞的活性。
The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3.
作者信息
Lattime E C, Pecoraro G A, Stutman O
出版信息
J Exp Med. 1983 Mar 1;157(3):1070-5. doi: 10.1084/jem.157.3.1070.
Abstract
Murine natural killer (NK) and natural cytotoxic (NC) cells showed different patterns of augmentation of lytic activity after preincubation for 24 h with either poly-IC, interleukin 2 (IL-2), or interleukin 3 (IL-3): (a) Poly-IC augmented only NK cells, with no effect on NC activity, as we have previously observed (4); (b) IL-2 augmented both NK and NC activity; and (c) IL-3 augmented only NC lysis, without affecting NK activity. In addition, both precursor and the augmented effector cells showed differences in expression of the Qa-5 surface marker: NK precursors and effectors are Qa 5+, whereas NC precursors and effector cells are Qa-5-.
摘要
将小鼠自然杀伤（NK）细胞和自然细胞毒性（NC）细胞分别与聚肌胞苷酸（poly-IC）、白细胞介素2（IL-2）或白细胞介素3（IL-3）预孵育24小时后，它们的溶解活性增强模式有所不同：（a）如我们之前观察到的（4），poly-IC仅增强NK细胞活性，对NC活性无影响；（b）IL-2增强NK和NC两者的活性；（c）IL-3仅增强NC细胞的裂解作用，而不影响NK细胞活性。此外，前体细胞和增强后的效应细胞在Qa-5表面标志物的表达上也存在差异：NK前体细胞和效应细胞为Qa 5+，而NC前体细胞和效应细胞为Qa-5-。
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本文引用的文献
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