Manroe B L, Weinberg A G, Rosenfeld C R, Browne R
J Pediatr. 1979 Jul;95(1):89-98. doi: 10.1016/s0022-3476(79)80096-7.
Reference ranges for absolute total neutrophils/mm3, absolute immature neutrophils/mm3, and the fraction of immature to total neutrophils (I:T proportion) during the first 28 days of life are developed from 585 peripheral blood counts obtained from 304 normal neonates and 320 counts obtained from 130 neonates with perinatal complications demonstrated to have no statistically significant effect on neutrophil dynamics. Perinatal factors other than bacterial disease which significantly alter neutrophil dynamics include maternal hypertension, maternal fever prior to delivery, hemolytic disease, and periventricular hemorrhage. The predictive value of these reference ranges in identifying bacterial disease in the first week of age varies with the neutrophil factor evaluated and the clinical setting. Neutropenia in the presence of respiratory distress in the first 72 hours had an 84% likelihood of signifying bacterial disease, whereas neutropenia in the presence of asphyxia had a 68% likelihood of signifying bacterial disease. An abnormal I:T proportion had an accuracy of 82% and 61%, respectively, in the same clinical settings. Elevations of either immature or total neutrophils were less specific. Interpretation of abnormal neutrophil factors must include consideration of both infectious and noninfectious perinatal events.
出生后前28天内，每立方毫米绝对总中性粒细胞、绝对未成熟中性粒细胞以及未成熟中性粒细胞与总中性粒细胞的比例（I:T比例）的参考范围，是根据从304名正常新生儿获得的585次外周血计数以及从130名有围产期并发症且经证实对中性粒细胞动态无统计学显著影响的新生儿获得的320次计数得出的。除细菌性疾病外，其他能显著改变中性粒细胞动态的围产期因素包括母亲高血压、分娩前母亲发热、溶血病和脑室周围出血。这些参考范围在识别出生后第一周细菌性疾病方面的预测价值，因所评估的中性粒细胞因素和临床情况而异。出生后72小时内出现呼吸窘迫时的中性粒细胞减少症，有84%的可能性表明患有细菌性疾病，而窒息时出现的中性粒细胞减少症，有68%的可能性表明患有细菌性疾病。在相同临床情况下，异常的I:T比例的准确率分别为82%和61%。未成熟或总中性粒细胞的升高特异性较低。对异常中性粒细胞因素的解读必须同时考虑感染性和非感染性围产期事件。
