Singh Aayushi, Nagpal Rema, Deshpande Sujata, Devhare Deepa, Thakar Vrushali H, Babu Aishwarya, Suryawanshi Pradeep K
Neonatology, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, IND.
Microbiology, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, IND.
Cureus. 2025 Jul 22;17(7):e88537. doi: 10.7759/cureus.88537. eCollection 2025 Jul.
Late-onset sepsis is an important cause of mortality and morbidity in neonates. Gram-positive organisms are increasingly being recognized as causing clinically significant sepsis. was first reported as a novel species of the genus and has not been reported to cause clinically significant infections in humans. This organism was reclassified as in 2020, following taxonomic changes. We report six neonates, all of whom developed sepsis with this organism. In our patients, the organism was identified with matrix-assisted laser desorption ionization time-of-flight mass spectroscopy (MALDI-TOF-MS) test and revealed a mild-to-moderate virulence pattern. The neonates had predominantly gastrointestinal symptoms, with blood culture positivity in five neonates, and one neonate had the organism in the cerebrospinal fluid. The clinical outcomes were favorable in all the neonates, but one neonate died due to unrelated complications. With the significant emergence of multidrug-resistant organisms and the increasing survival of smaller neonates, this organism may become more significant as a causative agent in NICUs.
晚发性败血症是新生儿死亡和发病的重要原因。革兰氏阳性菌越来越被认为是导致具有临床意义的败血症的原因。最初被报道为属的一个新物种，尚未有该菌导致人类临床显著感染的报道。随着分类学的变化，该菌于2020年被重新分类为。我们报告了6例新生儿，他们均因该菌发生了败血症。在我们的患者中，通过基质辅助激光解吸电离飞行时间质谱（MALDI-TOF-MS）检测鉴定出该菌，并显示出轻度至中度的毒力模式。这些新生儿主要有胃肠道症状，5例新生儿血培养呈阳性，1例新生儿脑脊液中发现该菌。所有新生儿的临床结局良好，但1例新生儿因无关并发症死亡。随着多重耐药菌的大量出现以及更小孕周新生儿存活率的提高，该菌作为新生儿重症监护病房（NICU）的病原体可能会变得更加重要。
