Cifuentes R F, Olley P M, Balfe J W, Radde I C, Soldin S J
J Pediatr. 1979 Oct;95(4):583-7. doi: 10.1016/s0022-3476(79)80775-1.
Renal function during indomethacin treatment was studied in 12 premature infants with patent ductus arteriosus. Decreases in urinary flow rate, GFR, and CH2O by 56, 27, and 66%, respectively, occurred during Indo therapy. Urinary excretion rates of ions were also reduced: Na by 70%, Cl by 79%, K by 40%. These changes were accompanied by slight decreases in plasma sodium concentration and osmolality. Except for GFR and urinary Na and osmolality, all these functions returned to pretreatment values one to two weeks after stopping the drug.
对12例动脉导管未闭的早产儿在吲哚美辛治疗期间的肾功能进行了研究。在吲哚美辛治疗期间，尿流率、肾小球滤过率（GFR）和自由水清除率（CH2O）分别下降了56%、27%和66%。离子的尿排泄率也降低：钠降低70%，氯降低79%，钾降低40%。这些变化伴随着血浆钠浓度和渗透压的轻微降低。除了GFR、尿钠和渗透压外，所有这些功能在停药后1至2周恢复到治疗前水平。
