John E G, Vasan U, Hastreiter A R, Bhat R, Evans M A
Pediatr Pharmacol (New York). 1984;4(1):11-9.
Selected parameters of renal function were studied in premature infants with a significant patent ductus arteriosus who were treated with intravenous indomethacin according to a specific protocol. Urine volume, glomerular filtration rate, urine sodium, and the fractional excretion of sodium were analyzed in 17; osmolar, sodium, and free water clearances in 8; and indomethacin pharmacokinetics in 7 premature infants. All renal function parameters analyzed decreased during indomethacin therapy: urine volume and glomerular filtration rate returned to normal, while urine sodium, fractional excretion of sodium, and the osmolar, sodium, and free water clearances remained low 24 hours after cessation of therapy. The water retention, shown by the reduced free water clearance, had no apparent deleterious effects, probably because of the infants' low fluid intake. Indomethacin pharmacokinetic parameters (clearance, area under the curve) may account in part for the variability of the fractional excretion of sodium, glomerular filtration, and urine flow rate.
根据特定方案，对患有显著动脉导管未闭且接受静脉注射吲哚美辛治疗的早产儿的肾功能相关参数进行了研究。分析了17例早产儿的尿量、肾小球滤过率、尿钠及钠排泄分数；8例的渗透清除率、钠清除率及自由水清除率；以及7例早产儿的吲哚美辛药代动力学。在吲哚美辛治疗期间，所有分析的肾功能参数均下降：尿量和肾小球滤过率恢复正常，而尿钠、钠排泄分数以及渗透清除率、钠清除率和自由水清除率在治疗停止24小时后仍保持较低水平。自由水清除率降低所显示的水潴留没有明显的有害影响，这可能是由于婴儿液体摄入量较低。吲哚美辛药代动力学参数（清除率、曲线下面积）可能部分解释了钠排泄分数、肾小球滤过和尿流率的变异性。
