Done A K, Yaffe S J, Clayton J M
J Pediatr. 1979 Oct;95(4):617-25. doi: 10.1016/s0022-3476(79)80783-0.
The labeled dosage schedule that has long been on pediatric aspirin preparations is at variance with the recommendation in authoritative medical references, studies demonstrating antipyretic effectiveness in children, and the prescribing habits of pediatricians as revealed by a poll conducted by the authors. Aspirin pharmacokinetics are influenced by a number of physiologic factors, as well as by dosage, and complicate the problem of assuring safe and effective pediatric use. Basic pharmacokinetic considerations indicate that the increase in size of individual doses needed to assure therapeutic salicyate blood levels, thereby removing the temptation of parents to administer the drug too often, is made permissible (i.e., safe while effective) by expanding the interdose interval to four hours instead of three. A revised pediatric aspirin disage schedule is presented that better meets the practices of the pediatric community and the needs of consumers.
长期以来儿科阿司匹林制剂上标注的剂量表与权威医学参考文献中的建议、表明对儿童有退热效果的研究以及作者进行的一项民意调查所揭示的儿科医生的处方习惯不一致。阿司匹林的药代动力学受多种生理因素以及剂量的影响，这使得确保儿科安全有效用药的问题变得复杂。基本的药代动力学考量表明，为确保治疗性水杨酸盐血药浓度而增加单次剂量，从而消除家长过于频繁给药的诱因，通过将给药间隔延长至四小时而非三小时是可行的（即安全且有效）。本文提出了一个修订后的儿科阿司匹林剂量表，它能更好地符合儿科界的实际做法和消费者的需求。
