Johnson R W, Keenan T H, Kosh J W, Sowell J W
J Pharm Sci. 1979 Aug;68(8):955-8. doi: 10.1002/jps.2600680810.
The synthesis and local anesthetic and antiarrhythmic properties of eight substituted 2-diethylaminoacetamido-3-carbamyl-4-methylpyrroles are described. Three compounds showed significant local anesthetic activity by the guinea pig wheal test, and four showed antiarrhythmic activity against chloroform-induced ventricular arrhythmias in mice.
