Synthesis of substituted 2-aminopyrrole analogs of lidocaine II.
作者信息
Johnson R W, Keenan T H, Kosh J W, Sowell J W
出版信息
J Pharm Sci. 1979 Aug;68(8):955-8. doi: 10.1002/jps.2600680810.
PMID:480174
Abstract
The synthesis and local anesthetic and antiarrhythmic properties of eight substituted 2-diethylaminoacetamido-3-carbamyl-4-methylpyrroles are described. Three compounds showed significant local anesthetic activity by the guinea pig wheal test, and four showed antiarrhythmic activity against chloroform-induced ventricular arrhythmias in mice.
摘要
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