Johnson R W, Keenan T H, Kosh J W, Sowell J W
J Pharm Sci. 1979 Mar;68(3):317-20. doi: 10.1002/jps.2600680316.
The synthesis, local anesthetic, and antiarrhythmic properties of nine 2-diethylaminoacetamido-3-cyano-4-methyl-5-substituted pyrroles are described. All compounds showed local anesthetic activity by the guinea pig wheal test and antiarrhythmic activity for chloroform-induced ventricular arrhythmias in mice.
