Synthesis of substituted 2-aminopyrrole analogs of lidocaine I.
作者信息
Johnson R W, Keenan T H, Kosh J W, Sowell J W
出版信息
J Pharm Sci. 1979 Mar;68(3):317-20. doi: 10.1002/jps.2600680316.
PMID:423119
Abstract
The synthesis, local anesthetic, and antiarrhythmic properties of nine 2-diethylaminoacetamido-3-cyano-4-methyl-5-substituted pyrroles are described. All compounds showed local anesthetic activity by the guinea pig wheal test and antiarrhythmic activity for chloroform-induced ventricular arrhythmias in mice.
摘要
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