Mann P G, Richens E R
Postgrad Med J. 1973 Aug;49(574):523-5. doi: 10.1136/pgmj.49.574.523.
Human brucellosis still presents difficulties in diagnosis and prevention. Townspeople may be infected by drinking raw milk while on holiday. Laboratory tests are still unsatisfactory as indicators of clinically active disease. High titre antibodies may be found without overt symptoms, particularly in persons occupationally exposed to repeated infection. In contrast, cases have been recorded in which no antibody appeared despite a positive blood culture. A preliminary study of leukocyte migration inhibition suggests that this may prove useful in detecting disease associated with low or absent antibodies, but is not likely to provide an infallible guide to clinical activity.
人类布鲁氏菌病在诊断和预防方面仍然存在困难。城镇居民在度假时饮用生牛奶可能会被感染。实验室检测作为临床活动性疾病的指标仍不尽人意。高滴度抗体可能在没有明显症状的情况下出现，尤其是在职业上反复接触感染的人群中。相比之下，也有血液培养呈阳性但未出现抗体的病例记录。一项关于白细胞游走抑制的初步研究表明，这可能有助于检测与低抗体或无抗体相关的疾病，但不太可能为临床活动性提供绝对可靠的指导。
