Turek F W, Desjardins C
J Natl Cancer Inst. 1979 Oct;63(4):969-75.
The age-dependent onset of spontaneous testicular interstitial cell tumors was examined in F344 male rats. Light microscopy of testes established that nodular interstitial cell hyperplasia was evident in 3 of 5 12-month-old rats and in 5 of 5 rats at 15, 18, 21, and 24 months of age. Involution of the seminiferous epithelium was evident in all testes exhibiting extensive interstitial cell proliferation. Striking increments in serum prolactin and estradiol levels were noted with advancing age, whereas serum levels of follicle-stimulating hormone were unequivocally lower at 21 and 24 months than at 6 months of age. No measurable changes were detected in serum testosterone concentrations between 6 and 18 months of age, but marked increments in this androgen, without any measurable change in circulating luteinizing hormone titers, were apparent in 21- and 24-month-old rats. These findings point to a dynamic relationship between testicular interstitial cell tumorigenesis and age-related changes in the synthesis and/or secretion of gonadal and adenohypophyseal hormones.
在F344雄性大鼠中研究了自发性睾丸间质细胞瘤的年龄依赖性发病情况。睾丸的光学显微镜检查显示，在5只12月龄大鼠中有3只出现明显的结节性间质细胞增生，而在15、18、21和24月龄的5只大鼠中均出现这种情况。在所有表现出广泛间质细胞增殖的睾丸中，生精上皮的退化很明显。随着年龄的增长，血清催乳素和雌二醇水平显著升高，而在21和24月龄时，血清促卵泡激素水平明显低于6月龄时。在6至18月龄之间，血清睾酮浓度未检测到可测量的变化，但在21和24月龄的大鼠中，这种雄激素显著增加，而循环黄体生成素滴度没有任何可测量的变化。这些发现表明睾丸间质细胞瘤发生与性腺和腺垂体激素合成和/或分泌的年龄相关变化之间存在动态关系。
