Tanaka N, Shingai F, Tamagawa M, Nakatsu I
J Toxicol Sci. 1979 Feb;4(1):47-58. doi: 10.2131/jts.4.47.
Carteolol was administered orally by gastric intubation at 3, 15, 75 or 150 mg/kg/day to ICR-JCL mice of both sexes prior to mating and to females during early stage of pregnancy to determine its effects on the entire reproductive process and fetal development. Following results were obtained: 1) The decrease of spontaneous motor activity was observed in all treatment groups, and some animals in the 75 mg/kg and 150 mg/kg groups pressed the chest or abdomen against the cage wall. 2) The incidence of early resorptions in the 75 mg/kg and 150 mg/kg groups was significantly higher than that in controls.3) The ossification of the talus and calcaneus was significantly retarded in the 75 mg/kg and 150 mg/kg groups. The maximum non-effective dose on fertility and reproduction for carteolol was estimated to be 15 mg/kg/day, although the incidence of early resorptions was slightly elevated with this dose.
在交配前，对雌雄ICR-JCL小鼠口服给予卡替洛尔，剂量为3、15、75或150mg/kg/天，对怀孕早期的雌性小鼠也给予相同处理，以确定其对整个生殖过程和胎儿发育的影响。获得以下结果：1）在所有治疗组中均观察到自发运动活动减少，75mg/kg和150mg/kg组中的一些动物将胸部或腹部压在笼壁上。2）75mg/kg和150mg/kg组的早期吸收发生率显著高于对照组。3）75mg/kg和150mg/kg组距骨和跟骨的骨化明显延迟。卡替洛尔对生育和生殖的最大无作用剂量估计为15mg/kg/天，尽管该剂量下早期吸收的发生率略有升高。
