Tamagawa M, Numoto T, Tanaka N, Nishino H
J Toxicol Sci. 1979 Feb;4(1):59-77. doi: 10.2131/jts.4.59.
Carteolol was orally administered to mice once a day at doses of 3, 30 and 150 mg/kg/day during the perinatal and lactation periods and evaluated on its adverse effects on pregnant animals and their offspring. No appreciably abnormal findings related to the drug administration were revealed. Therefore, it was concluded that carteolol have no serious toxic potential on parturition and lactation by mother animals, no adverse effects on growth and development, and behavioral and reproductive performance of offspring and no carcinogenic action through placental and milk transfer.
在围产期和哺乳期，每天一次以3、30和150毫克/千克/天的剂量给小鼠口服Carteolol，并评估其对怀孕动物及其后代的不良反应。未发现与给药相关的明显异常结果。因此，得出结论，Carteolol对母兽的分娩和哺乳没有严重的潜在毒性，对后代的生长发育、行为和生殖性能没有不良影响，并且不会通过胎盘和乳汁转移产生致癌作用。
