Finn R
Lancet. 1975 Apr 12;1(7911):835-8. doi: 10.1016/s0140-6736(75)93006-8.
A hypothesis is put forward to account for the non-rejection of the fetal allograft, based on shared surface-repellent molecules (S.R.M.s) which prevent close apposition of maternal and fetal immunocompetent cells. This hypothesis is shown to be compatible with the major theoretical requirements of the immune system. Thus it provides possible explanations for the self/not-self recognition process, tolerance to organ transplants, the development of autoimmune disease, and high and low zone tolerance. It is also argued that the recognition of self is important with reference to cellular antigens, but may not be essential for humoral antigens.
基于共享表面排斥分子（S.R.M.s）提出了一个假说，用以解释胎儿同种异体移植不被排斥的现象，这些分子可阻止母体和胎儿免疫活性细胞紧密毗邻。该假说被证明与免疫系统的主要理论要求相符。因此，它为自身/非自身识别过程、对器官移植的耐受性、自身免疫性疾病的发展以及高低带耐受提供了可能的解释。还有观点认为，对于细胞抗原而言，自身识别很重要，但对于体液抗原可能并非必不可少。
