Krustinov G, Gringorov M, Andreev A, Simeonov E, Bogdanov N
Eksp Med Morfol. 1973;12(3):150-5.
The authors induced acute blood loss in dogs and examined the changes in hemodynamics, hemodilution, blood coagulation acid-base balance and tissue respiration. They found that the most favourable hours for initial renimation were the first two hours. They used the Bulgarian plasma substitute reoisodex with very good effect on the indicated parameters and microcirculation. As a result of this the time for the appearence of irreversible stage in grave hypovolemia was prolonged with hours.
作者们使狗发生急性失血，并检测了血流动力学、血液稀释、血液凝固、酸碱平衡及组织呼吸的变化。他们发现最初复苏的最有利时机是头两个小时。他们使用了保加利亚血浆代用品雷奥索德克斯，对上述指标及微循环有很好的效果。结果，严重低血容量时不可逆阶段出现的时间延长了数小时。
