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Synthesis of tritium-labeled chlorambucil and aniline mustard of high specific activity.

作者信息

Jarman M, Griggs L J, Tisdale M J

出版信息

J Med Chem. 1974 Feb;17(2):194-7. doi: 10.1021/jm00248a010.

DOI:10.1021/jm00248a010
PMID:4809255
Abstract
摘要

相似文献

1
Synthesis of tritium-labeled chlorambucil and aniline mustard of high specific activity.高比活度氚标记苯丁酸氮芥及苯胺氮芥的合成。
J Med Chem. 1974 Feb;17(2):194-7. doi: 10.1021/jm00248a010.
2
Electrospray mass spectrometric analysis of new alpha-MSH analogues carrying nitrogen mustard at their amino terminus.对在其氨基末端带有氮芥的新型α-促黑素细胞激素类似物进行电喷雾质谱分析。
Pept Res. 1994 Jan-Feb;7(1):7-12.
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Synthesis of 4-[p-[(2-chloroethyl)-(2-hydroxyethyl)amino]phenyl]butyric acid and its behavior in the 4-(4-nitrobenzyl)pyridine assay procedure.4-[对-[(2-氯乙基)-(2-羟乙基)氨基]苯基]丁酸的合成及其在4-(4-硝基苄基)吡啶测定法中的行为。
J Pharm Sci. 1970 Apr;59(4):563-5. doi: 10.1002/jps.2600590429.
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Metabolism of aniline mustard (N,N-di-(2-chloroethyl)aniline).苯胺氮芥(N,N-二(2-氯乙基)苯胺)的代谢
Biochem Pharmacol. 1973 Aug 15;22(16):1971-80. doi: 10.1016/0006-2952(73)90079-8.
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Selectivity of action of alkylating agents and drug resistance. 4. Synthesis of tritium-labeled chlorambucil and a study of its cellular uptake by drug-sensitive and drug-resistant strains of the Yoshida ascites sarcoma in vitro.烷化剂的作用选择性与耐药性。4. 氚标记苯丁酸氮芥的合成及其对吉田腹水肉瘤敏感株和耐药株细胞摄取的体外研究。
J Med Chem. 1971 Jul;14(17):614-8-. doi: 10.1021/jm00289a012.
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[Research on compounds with antiblastic activity. XLI. Synthesis of new nitrogen mustards correlated with N,N-bis-(beta-chlorethyl) aniline].
Farmaco Sci. 1971 Sep;26(9):805-11.
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Novel melphalan and chlorambucil derivatives of 2,2,6,6-tetramethyl-1-piperidinyloxy radicals: synthesis, characterization, and biological evaluation in vitro.
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Research on compounds with antiblastic activity. XL. Synthesis of 3-p-(2',5'-dimethoxy-4'-(N,N-bis-( -chloroethyl)-amino)benzylideneamino)phenyl-2-oxazolidinone (GEA 29 ; BAY a 5850) and its analogues.
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Yao Xue Xue Bao. 1979 Nov;14(11):676-81.

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1
The pharmacokinetics of prednimustine and chlorambucil in the rat.
Cancer Chemother Pharmacol. 1981;6(1):85-91. doi: 10.1007/BF00253015.
2
[Concentrations of cytostatic drugs in organs and tumors: comparison after intravenous and intratumoral injection (author's transl)].[细胞毒性药物在器官和肿瘤中的浓度:静脉注射和瘤内注射后的比较(作者译)]
J Cancer Res Clin Oncol. 1979 Oct;95(2):147-57. doi: 10.1007/BF00401009.