烷化剂的作用选择性与耐药性。4. 氚标记苯丁酸氮芥的合成及其对吉田腹水肉瘤敏感株和耐药株细胞摄取的体外研究。 - Suppr | 超能文献

Selectivity of action of alkylating agents and drug resistance. 4. Synthesis of tritium-labeled chlorambucil and a study of its cellular uptake by drug-sensitive and drug-resistant strains of the Yoshida ascites sarcoma in vitro.

作者信息

Hill B T, Jarman M, Harrap K R

出版信息

J Med Chem. 1971 Jul;14(17):614-8-. doi: 10.1021/jm00289a012.

DOI:10.1021/jm00289a012

Abstract

摘要

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1

Selectivity of action of alkylating agents and drug resistance. 4. Synthesis of tritium-labeled chlorambucil and a study of its cellular uptake by drug-sensitive and drug-resistant strains of the Yoshida ascites sarcoma in vitro.烷化剂的作用选择性与耐药性。4. 氚标记苯丁酸氮芥的合成及其对吉田腹水肉瘤敏感株和耐药株细胞摄取的体外研究。

J Med Chem. 1971 Jul;14(17):614-8-. doi: 10.1021/jm00289a012.

2

Studies on the transport and cellular distribution of chlorambucil in the Yoshida ascites sarcoma.苯丁酸氮芥在吉田腹水肉瘤中的转运及细胞分布研究。

Biochem Pharmacol. 1972 Feb 15;21(4):495-502. doi: 10.1016/0006-2952(72)90322-x.

3

The absorption, distribution and excretion of 3 H-chlorambucil in rats bearing the Yoshida ascites sarcoma.3H-苯丁酸氮芥在吉田腹水肉瘤大鼠体内的吸收、分布及排泄情况。

Br J Cancer. 1971 Dec;25(4):831-7. doi: 10.1038/bjc.1971.96.

4

The selectivity of action of alkylating agents and drug resistance. 3. The uptake and degradation of alkylating drugs by Yoshida ascites sarcoma cells in vitro.烷化剂作用的选择性与耐药性。3. 体外吉田腹水肉瘤细胞对烷化剂药物的摄取与降解。

Biochem Pharmacol. 1970 Jan;19(1):209-17. doi: 10.1016/0006-2952(70)90341-2.

5

An autoradiographic study of the binding of 3-H-chlorambucil to cells of a drug-sensitive and drug-resistant strain of the Yoshida ascites sarcoma.一项关于³H-苯丁酸氮芥与吉田腹水肉瘤的药物敏感株和耐药株细胞结合的放射自显影研究。

J Microsc. 1975 Mar;103(2):239-48. doi: 10.1111/j.1365-2818.1975.tb03899.x.

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The binding of (3H)chlorambucil to isolated nuclear proteins of the Yoshida ascites sarcoma.（3H）苯丁酸氮芥与吉田腹水肉瘤分离核蛋白的结合。

Biochem Soc Trans. 1975;3(5):649-51. doi: 10.1042/bst0030649.

7

The binding of [3H]chlorambucil to nuclear proteins of the Yoshida ascites sarcoma.[3H]苯丁酸氮芥与吉田腹水肉瘤细胞核蛋白的结合。

Chem Biol Interact. 1975 Oct;11(4):291-9. doi: 10.1016/0009-2797(75)90082-4.

8

Differential effects of cytotoxic concentrations of chlorambucil on drug-resistant and drug-sensitive cell lines of the Yoshida ascites sarcoma in culture.苯丁酸氮芥细胞毒性浓度对培养的吉田腹水肉瘤耐药和药物敏感细胞系的不同影响。

Eur J Cancer (1965). 1975 Jan;11(1):91-6. doi: 10.1016/0014-2964(75)90031-6.

9

The selectivity of action of alkylating agents and drug resistance. I. Biochemical changes occurring in sensitive and resistant strains of the Yoshida ascites sarcoma following chemotherapy.烷化剂作用的选择性与耐药性。I. 化疗后吉田腹水肉瘤敏感株和耐药株中发生的生化变化。

Br J Cancer. 1969 Mar;23(1):210-26. doi: 10.1038/bjc.1969.30.

10

Some effects of chlorambucil on nuclear protein phosphorylation in the Yoshida ascites sarcoma.苯丁酸氮芥对吉田腹水肉瘤细胞核蛋白磷酸化的某些作用。

Chem Biol Interact. 1977 Jul;18(1):11-22. doi: 10.1016/0009-2797(77)90137-5.

引用本文的文献

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Modulation of the toxicity and antitumour activity of alkylating drugs by steroids.类固醇对烷化剂药物毒性和抗肿瘤活性的调节作用。

Br J Cancer. 1982 Mar;45(3):413-20. doi: 10.1038/bjc.1982.69.

2

The absorption, distribution and excretion of 3 H-chlorambucil in rats bearing the Yoshida ascites sarcoma.3H-苯丁酸氮芥在吉田腹水肉瘤大鼠体内的吸收、分布及排泄情况。

Br J Cancer. 1971 Dec;25(4):831-7. doi: 10.1038/bjc.1971.96.

3

Tissue distribution and nucleic acid binding of chlorambucil-3H in tumor-bearing rats.荷瘤大鼠中苯丁酸氮芥-3H的组织分布及核酸结合情况

Experientia. 1978 Sep 15;34(9):1215-6. doi: 10.1007/BF01922965.