由庆大霉素乙酰转移酶II介导的细菌对氨基糖苷类抗生素的耐药性，该酶可修饰氨基糖苷类抗生素的2'-氨基基团。 - Suppr

Suppr

超能文献

Aminoglycoside resistance in bacteria medicated by gentamicin acetyltransferase II, an enzyme modifying the 2'-amino group of aminoglycoside antibiotics.

作者信息

Chevereau M, Daniels P J, Davies J, LeGoffic F

出版信息

Biochemistry. 1974 Jan 29;13(3):598-603. doi: 10.1021/bi00700a030.

DOI:10.1021/bi00700a030

PMID:4810068

Abstract

摘要

相似文献

Aminoglycoside resistance in bacteria medicated by gentamicin acetyltransferase II, an enzyme modifying the 2'-amino group of aminoglycoside antibiotics.由庆大霉素乙酰转移酶II介导的细菌对氨基糖苷类抗生素的耐药性，该酶可修饰氨基糖苷类抗生素的2'-氨基基团。

Biochemistry. 1974 Jan 29;13(3):598-603. doi: 10.1021/bi00700a030.

3-N enzymatic acetylation of gentamicin, tobramycin, and kanamycin by Escherichia coli carrying an R factor.携带R因子的大肠杆菌对庆大霉素、妥布霉素和卡那霉素的3-N酶促乙酰化作用

Antimicrob Agents Chemother. 1974 Dec;6(6):680-4. doi: 10.1128/AAC.6.6.680.

Effect of structural modifications on the biological properties of aminoglycoside antibiotics containing 2-deoxystreptamine.结构修饰对含2-脱氧链霉胺的氨基糖苷类抗生素生物学性质的影响

Adv Appl Microbiol. 1974;18(0):191-307. doi: 10.1016/s0065-2164(08)70572-0.

[Resistance to aminosides induced by an isoenzyme, kanamycin acetyltransferase].[由一种同工酶，卡那霉素乙酰转移酶诱导产生的对氨基糖苷类抗生素的耐药性]

Biochimie. 1974;56(6-7):893-7. doi: 10.1016/s0300-9084(74)80512-2.

[The role of aminoglycoside--modifying enzymes in resistance of Gram-negative rods].[氨基糖苷类修饰酶在革兰氏阴性杆菌耐药中的作用]

Med Dosw Mikrobiol. 2006;58(4):363-70.

pH modulation of aminoglycoside resistance in Staphylococcus epidermidis harbouring 6'-N-aminoglycoside acetyltransferase.携带6'-N-氨基糖苷乙酰转移酶的表皮葡萄球菌中氨基糖苷耐药性的pH调节

J Antimicrob Chemother. 1996 May;37(5):881-9. doi: 10.1093/jac/37.5.881.

Studies of enzymes that cause resistance to aminoglycosides antibiotics.对导致对氨基糖苷类抗生素产生耐药性的酶的研究。

Methods Mol Med. 2008;142:261-71. doi: 10.1007/978-1-59745-246-5_20.

Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria.放线菌中与耐药临床分离菌中存在的那些酶类似的氨基糖苷类抗生素失活酶。

Proc Natl Acad Sci U S A. 1973 Aug;70(8):2276-80. doi: 10.1073/pnas.70.8.2276.

Modification of aminoglycoside antibiotics by clinical isolates of Streptococcus faecalis.粪肠球菌临床分离株对氨基糖苷类抗生素的修饰作用。

J Antibiot (Tokyo). 1981 Feb;34(2):224-30. doi: 10.7164/antibiotics.34.224.

Correlation of antibiotic resistance with Vmax/Km ratio of enzymatic modification of aminoglycosides by kanamycin acetyltransferase.抗生素耐药性与卡那霉素乙酰转移酶对氨基糖苷类进行酶促修饰的Vmax/Km比值之间的相关性。

Antimicrob Agents Chemother. 1984 Apr;25(4):479-82. doi: 10.1128/AAC.25.4.479.

引用本文的文献

Small-Molecule Acetylation by GCN5-Related -Acetyltransferases in Bacteria.细菌中 GCN5 相关乙酰转移酶的小分子乙酰化作用。

Microbiol Mol Biol Rev. 2020 Apr 15;84(2). doi: 10.1128/MMBR.00090-19. Print 2020 May 20.

Overexpression and characterization of the chromosomal aminoglycoside 2'-N-acetyltransferase of Providencia stuartii.斯氏普罗威登斯菌染色体氨基糖苷2'-N-乙酰基转移酶的过表达及特性分析

Antimicrob Agents Chemother. 2001 Aug;45(8):2238-44. doi: 10.1128/AAC.45.8.2238-2244.2001.

Activation of the 2'-N-acetyltransferase gene [aac(2')-Ia] in Providencia stuartii by an interaction of AarP with the promoter region.通过AarP与启动子区域的相互作用激活斯氏普罗威登斯菌中的2'-N-乙酰转移酶基因[aac(2')-Ia] 。

Antimicrob Agents Chemother. 1999 Jul;43(7):1769-72. doi: 10.1128/AAC.43.7.1769.

Mutations in aarE, the ubiA homolog of Providencia stuartii, result in high-level aminoglycoside resistance and reduced expression of the chromosomal aminoglycoside 2'-N-acetyltransferase.斯氏普罗威登斯菌的泛醌生物合成酶A同源物aarE发生突变，会导致高水平氨基糖苷耐药性，并使染色体氨基糖苷2'-N-乙酰转移酶的表达降低。

Antimicrob Agents Chemother. 1998 Apr;42(4):959-62. doi: 10.1128/AAC.42.4.959.

Identification and characterization of aarF, a locus required for production of ubiquinone in Providencia stuartii and Escherichia coli and for expression of 2'-N-acetyltransferase in P. stuartii.鉴定和表征aarF，这是一个在斯氏普罗威登斯菌和大肠杆菌中参与泛醌合成以及在斯氏普罗威登斯菌中参与2'-N-乙酰转移酶表达所必需的基因座。

J Bacteriol. 1998 Jan;180(1):128-35. doi: 10.1128/JB.180.1.128-135.1998.

An extracellular factor regulating expression of the chromosomal aminoglycoside 2'-N-acetyltransferase of Providencia stuartii.一种调节斯氏普罗威登斯菌染色体氨基糖苷2'-N-乙酰基转移酶表达的细胞外因子。

Antimicrob Agents Chemother. 1997 Aug;41(8):1749-54. doi: 10.1128/AAC.41.8.1749.

Characterization of gentamicin 2'-N-acetyltransferase from Providencia stuartii: its use of peptidoglycan metabolites for acetylation of both aminoglycosides and peptidoglycan.斯氏普罗威登斯菌庆大霉素2'-N-乙酰基转移酶的特性：其利用肽聚糖代谢产物对氨基糖苷类和肽聚糖进行乙酰化作用。

J Bacteriol. 1997 Jul;179(13):4106-14. doi: 10.1128/jb.179.13.4106-4114.1997.

aarC, an essential gene involved in density-dependent regulation of the 2'-N-acetyltransferase in Providencia stuartii.aarC，一个参与斯氏普罗威登斯菌中2'-N-乙酰转移酶密度依赖性调控的必需基因。

J Bacteriol. 1997 Apr;179(7):2267-73. doi: 10.1128/jb.179.7.2267-2273.1997.

Characterization and transcriptional regulation of the 2'-N-acetyltransferase gene from Providencia stuartii.斯氏普罗威登斯菌2'-N-乙酰基转移酶基因的特性与转录调控

J Bacteriol. 1993 Oct;175(20):6492-8. doi: 10.1128/jb.175.20.6492-6498.1993.

Identification and analysis of aarP, a transcriptional activator of the 2'-N-acetyltransferase in Providencia stuartii.斯氏普罗威登斯菌中2'-N-乙酰转移酶转录激活因子aarP的鉴定与分析。

J Bacteriol. 1995 Jun;177(12):3407-13. doi: 10.1128/jb.177.12.3407-3413.1995.

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