Brunzell J D, Porte D, Bierman E L
Metabolism. 1979 Sep;28(9):901-7. doi: 10.1016/0026-0495(79)90089-1.
Hypertriglyceridemia is common in untreated diabetes mellitus. An abnormality in the interaction of lipoprotein lipase with endogenous circulating plasma lipoprotein triglyceride has been demonstrated in untreated diabetes. These diabetics have a decreased maximal removal capacity for plasma triglyceride (27.0 mg TG/kh/hr) and increased Km (390 mg/dl) for endogenous plasma triglyceride-lipoprotein lipase interaction compared to that found in nondiabetic hypertriglyceridemic subjects (Vmax, 32.0; km, 157). Diabetics treated for at least two months have a maximal removal capacity and Km similar to that of nondiabetic subjects (Vmax, 32.7; Km, 192). No evidence for an increase in triglyceride production due to diabetes per se was found. When diabetic subjects with triglyceride levels over 400 mg/dl were selected for study, most were found to have an independent familial form of hypertriglyceridemia.
高甘油三酯血症在未经治疗的糖尿病患者中很常见。在未经治疗的糖尿病患者中，已证实脂蛋白脂肪酶与内源性循环血浆脂蛋白甘油三酯之间的相互作用存在异常。与非糖尿病性高甘油三酯血症患者相比，这些糖尿病患者对血浆甘油三酯的最大清除能力降低（27.0毫克甘油三酯/千克/小时），内源性血浆甘油三酯-脂蛋白脂肪酶相互作用的米氏常数（Km）增加（390毫克/分升）（最大反应速度Vmax，32.0；Km，157）。接受至少两个月治疗的糖尿病患者的最大清除能力和Km与非糖尿病患者相似（Vmax，32.7；Km，192）。未发现糖尿病本身导致甘油三酯生成增加的证据。当选择甘油三酯水平超过400毫克/分升的糖尿病患者进行研究时，发现大多数患者患有独立的家族性高甘油三酯血症。
