Forest M G, Sizonenko P C, Cathiard A M, Bertrand J
J Clin Invest. 1974 Mar;53(3):819-28. doi: 10.1172/JCI107621.
Total and unbound testosterone and Delta(4)-androstenedione have been determined in 104 cord blood samples. The same sexual steroids and pituitary gonadotropins have been measured in 46 normal male infants aged 27-348 days and 34 normal female infants aged 19-332 days. In cord blood of female neonates mean total and unbound testosterone was 29.6+/-7.5 and 0.89+/-0.4 ng/100 ml, respectively (mean+/-1 SD); Delta(4)-androstenedione was 93+/-38 ng/100 ml. In male neonates mean plasma total and unbound testosterone was 38.9+/-10.8 and 1.12+/-0.4 ng/100 ml; Delta(4)-androstenedione was 85+/-27 ng/100 ml. In female infants testosterone concentrations remained constant during the 1st yr of life with a mean concentration of 7+/-3 ng/100 ml. Mean unbound testosterone and Delta(4)-androstenedione concentrations were 0.05+/-0.03 and 16.7+/-8.3 ng/100 ml, respectively. Mean plasma levels of follicle-stimulating hormone and luteinizing hormone were 8.7+/-3.3 and 12.9+/-7.7 mU/ml. In male infants mean plasma total testosterone concentration increased to 208+/-68 ng/100 ml from birth to 1-3 mo of age, decreasing thereafter to 95+/-53 ng/100 ml at 3-5 mo, 23.2+/-18 ng/100 ml at 5-7 mo, and reached prepubertal levels (6.6+/-4.6 ng/100 ml) at 7-12 mo. Mean unbound testosterone concentration plateaued from birth to 1-3 mo of age (1.3+/-0.2 ng/100 ml) decreasing to prepubertal values very rapidly. Mean Delta(4)-androstenedione concentration, although progressively decreasing during the 1st yr of life to 11.7+/-4.5 ng/100 ml, was higher than in the female at 1-3 mo of life (34+/-11 ng/100 ml). Mean plasma level of follicle-stimulating hormone was 6.7+/-2.9 mU/ml, and that of luteinizing hormone was 19.7+/-13.5 mU/ml, significantly higher than in the female. There was no correlation between gonadotropin and age or testosterone. The present data demonstrate that the testes are active during the first natal period. It is tempting to correlate this phenomenon to a progressive maturation of the hypothalamo-pituitary-gonadal axis. It is possible that the surge in testosterone occurring the first 3 mo could play a role in the future life pattern of the male human being.
已对104份脐带血样本中的总睾酮、游离睾酮和δ4-雄烯二酮进行了测定。对46名年龄在27至348天的正常男婴和34名年龄在19至332天的正常女婴测定了相同的性类固醇和垂体促性腺激素。在女新生儿的脐带血中，总睾酮和游离睾酮的平均水平分别为29.6±7.5和0.89±0.4 ng/100 ml（均值±1标准差）；δ4-雄烯二酮为93±38 ng/100 ml。在男新生儿中，血浆总睾酮和游离睾酮的平均水平分别为38.9±10.8和1.12±0.4 ng/100 ml；δ4-雄烯二酮为85±27 ng/100 ml。女婴在出生后第1年睾酮浓度保持恒定，平均浓度为7±3 ng/100 ml。游离睾酮和δ4-雄烯二酮的平均浓度分别为0.05±0.03和16.7±8.3 ng/100 ml。促卵泡激素和促黄体生成素的平均血浆水平分别为8.7±3.3和12.9±7.7 mU/ml。男婴出生时血浆总睾酮平均浓度为208±68 ng/100 ml，至1至3月龄时升至最高，此后在3至5月龄降至95±53 ng/100 ml，5至7月龄降至23.2±18 ng/100 ml，并在7至12月龄达到青春期前水平（6.6±4.6 ng/100 ml）。游离睾酮平均浓度在出生至1至3月龄时保持稳定（1.3±0.2 ng/100 ml），之后迅速降至青春期前水平。δ4-雄烯二酮平均浓度在出生后第1年虽逐渐下降至11.7±4.5 ng/100 ml，但在1至3月龄时高于女婴（34±11 ng/100 ml）。促卵泡激素平均血浆水平为6.7±2.9 mU/ml，促黄体生成素为19.7±13.5 mU/ml，显著高于女婴。促性腺激素与年龄或睾酮之间无相关性。目前的数据表明，出生后第一个阶段睾丸是活跃的。很容易将这种现象与下丘脑-垂体-性腺轴的逐渐成熟联系起来。出生后前3个月出现的睾酮激增可能对男性未来的生活模式有影响。
