Buckler J M, Clayton B E
Arch Dis Child. 1970 Aug;45(242):478-84. doi: 10.1136/adc.45.242.478.
Estimations by radioimmunoassay of the 24-hour excretion of LH in normal children (152 boys and 104 girls) have shown high values in the first six months of life in boys, and possibly girls, and then low levels until the age of about 6 years. There is then a gradual rise in LH excretion in both sexes which continues for the 3-4 years which precede the onset of puberty, at which age a more marked increase occurs. 13 cases of true precocious puberty were all found to be associated with increased urinary excretion of LH, a feature that was seldom shown with other forms of advanced sexual development. Measurement of urinary LH excretion provides a useful tool in the differentiation of such conditions.
通过放射免疫分析法对正常儿童（152名男孩和104名女孩）24小时促黄体生成素（LH）排泄量的测定显示，男孩在出生后的头六个月LH排泄量较高，女孩可能也是如此，然后在大约6岁之前LH水平较低。此后，两性的LH排泄量逐渐上升，在青春期开始前的3至4年持续上升，到青春期时会出现更明显的增加。13例真性性早熟病例均被发现与尿LH排泄增加有关，这一特征在其他形式的性发育提前中很少出现。测定尿LH排泄量为区分这些情况提供了一种有用的工具。
