Battistin L, Varotto M, Tezzon F, Pistollato L
Neurochem Res. 1979 Aug;4(4):457-64. doi: 10.1007/BF00964640.
In a study of the role of taurine in the genesis of epilepsy the effects of metrazol-induced convulsions on the uptake and distribution of taurine in the brain were measured. In vivo we found no significant uptake of taurine in the mouse brain; in rabbit brain in most areas significant taurine uptake was found. The physiological levels of taurine were much higher in mouse brain than in rabbit brain. In vivo the regional levels and the uptake of taurine were not significantly changed after generalized convulsions. Uptake in vivo was lowered in slices obtained from mice treated with metrazol. The lack of effect of metrazol convulsions on cerebral taurine in vivo indicates that further studies are needed to clarify the relationship between taurine, a putative inhibitory transmitter, and epilepsy.
在一项关于牛磺酸在癫痫发病机制中作用的研究中，测定了戊四氮诱发惊厥对牛磺酸在脑内摄取和分布的影响。在体内实验中，我们发现小鼠脑内牛磺酸摄取无显著变化；在兔脑的大多数区域，发现有显著的牛磺酸摄取。小鼠脑内牛磺酸的生理水平远高于兔脑。全身性惊厥后，体内牛磺酸的区域水平和摄取无显著变化。用戊四氮处理的小鼠脑片的体内摄取降低。戊四氮惊厥对体内脑牛磺酸无影响，这表明需要进一步研究以阐明牛磺酸（一种假定的抑制性递质）与癫痫之间的关系。
