Battistin L, Varotto M, Lorenzi A D
Brain Res. 1975 May 23;89(2):215-24. doi: 10.1016/0006-8993(75)90714-3.
The levels of the free amino acids of the mouse brain were studied after convulsions induced by Metrazol; a decrease of level of taurine and a significant increase of level of alanine, phenylalanine and isoleucine were found. The net uptake of L-histidine by the mouse brain in vivo was similar under normal conditions and after Metrazol-induced generalized convulsions; that of L-methionine was much higher after convulsions and there was no uptake of L-aspartic acid, either under physiological conditions or after convulsions. The net uptake of L-histidine by various regions of the rabbit brain in vivo after convulsions was significantly higher than control values in the cortical areas, while that of L-methionine was significantly higher in the subcortical ones; there was no uptake of L-aspartic acid by the rabbit brain in normal condition, whereas after convulsions a small entry seemed to occur in the subcortical areas. These results indicate that cerebral permeability processes of amino acids are somewhat altered during convulsive phenomena, as already described elsewhere for ions andproteins.
研究了戊四氮诱发惊厥后小鼠脑内游离氨基酸的水平；发现牛磺酸水平降低，而丙氨酸、苯丙氨酸和异亮氨酸水平显著升高。在正常条件下和戊四氮诱发全身性惊厥后，小鼠脑内L-组氨酸的净摄取量相似；惊厥后L-蛋氨酸的净摄取量高得多，且在生理条件下或惊厥后均未摄取L-天冬氨酸。惊厥后兔脑各区域L-组氨酸的体内净摄取量在皮质区域显著高于对照值，而L-蛋氨酸在皮质下区域显著更高；兔脑在正常情况下不摄取L-天冬氨酸，而惊厥后在皮质下区域似乎有少量进入。这些结果表明，氨基酸的脑通透性过程在惊厥现象期间有所改变，正如其他地方已描述的离子和蛋白质的情况一样。
