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Transamination is a major pathway of L-dopa metabolism following peripheral decarboxylase inhibition.

作者信息

Sandler M, Johnson R D, Ruthven C R, Reid J L, Calne D B

出版信息

Nature. 1974 Feb 8;247(5440):364-6. doi: 10.1038/247364b0.

DOI:10.1038/247364b0
PMID:4817854
Abstract
摘要

相似文献

1
Transamination is a major pathway of L-dopa metabolism following peripheral decarboxylase inhibition.
Nature. 1974 Feb 8;247(5440):364-6. doi: 10.1038/247364b0.
2
Inhibition of a minor pathway of L-dopa metabolism in the intestinal lumen using a decarboxylase inhibitor (Ro 4-4602).
J Pharm Pharmacol. 1974 May;26(5):377-9. doi: 10.1111/j.2042-7158.1974.tb09298.x.
3
Suppression of noradrenaline synthesis in sympathetic nerves by carbidopa, an inhibitor of peripheral dopa decarboxylase.外周多巴脱羧酶抑制剂卡比多巴对交感神经中去甲肾上腺素合成的抑制作用。
Nature. 1977 Jan 6;265(5589):79-80. doi: 10.1038/265079a0.
4
Carbidopa attenuation of L-DOPA emesis in dogs: evidence for a cerebral site of action outside the blood-brain barrier.
Eur J Pharmacol. 1974 Mar;25(3):322-5. doi: 10.1016/0014-2999(74)90262-3.
5
Altered pattern of dopa metabolism.多巴代谢模式改变。
Biochem Pharmacol. 1976 Jan 15;25(2):222-3. doi: 10.1016/0006-2952(76)90301-4.
6
Iso-homovanillic acid determination in cerebrospinal fluid and in urine during L-DOPA treatment of Parkinson's disease.
Clin Chim Acta. 1973 Nov 15;48(4):427-31. doi: 10.1016/0009-8981(73)90422-1.
7
[Parkinsonism and plasma metabolism of dihydroxyphenylalanine administered with an inhibitor of decarboxylase].
Clin Chim Acta. 1971 Jun;33(1):111-5. doi: 10.1016/0009-8981(71)90257-9.
8
[Effect of VB6 on L-DOPA decarboxylase activity in the organs of rats given peripheral L-DOPA decarboxylase inhibitors (author's transl)].
Nihon Ronen Igakkai Zasshi. 1978 Nov;15(6):566-73. doi: 10.3143/geriatrics.15.566.
9
Aterial blood pressure in dogs: effects of m-tyrosine alone or in combination with inhibitors of aromatic amino acid decarboxylase; relative hypotensive potencies of L-dopa, DL-m-tyrosine, and L-m-tyrosine.
Experientia. 1974 Sep 15;30(9):1051-3. doi: 10.1007/BF01939004.
10
[Urinary excretion of 3,4-dihydroxyphenyl-alanine, 3-O-methyldopa, dopamine and homovanillic acid in man. Effects of an inhibitor of decarboxylase of aromatic amino acids (Benserazide) (author's transl)].
J Clin Chem Clin Biochem. 1976 Nov;14(11):543-7.

引用本文的文献

1
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism.发现并抑制物种间肠道细菌左旋多巴代谢途径。
Science. 2019 Jun 14;364(6445). doi: 10.1126/science.aau6323.
2
Pharmacokinetics, metabolism and safety of deuterated L-DOPA (SD-1077)/carbidopa compared to L-DOPA/carbidopa following single oral dose administration in healthy subjects.在健康受试者中单次口服给予氘代 L-DOPA（SD-1077）/卡比多巴与 L-DOPA/卡比多巴的药代动力学、代谢和安全性比较。
Br J Clin Pharmacol. 2018 Oct;84(10):2422-2432. doi: 10.1111/bcp.13702. Epub 2018 Aug 9.
3
Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease.
用于治疗帕金森病的药物的临床药代动力学和药效学特性。
Clin Pharmacokinet. 2002;41(4):261-309. doi: 10.2165/00003088-200241040-00003.
4
In vivo effects of new inhibitors of catechol-O-methyl transferase.儿茶酚-O-甲基转移酶新型抑制剂的体内效应
Br J Pharmacol. 1999 Apr;126(7):1667-73. doi: 10.1038/sj.bjp.0702474.
5
The effect of carbidopa and benserazide on human plasma 5-hydroxytryptophan levels.
J Neural Transm. 1982;53(1):83-7. doi: 10.1007/BF01243522.
6
Chronic L-DOPA treatment of mice: a behavioural and biochemical study.小鼠的慢性左旋多巴治疗：一项行为学和生物化学研究。
J Neural Transm. 1981;50(2-4):209-24. doi: 10.1007/BF01249143.
7
Clinical pharmacokinetics of anti-parkinsonian drugs.抗帕金森病药物的临床药代动力学
Clin Pharmacokinet. 1987 Sep;13(3):141-78. doi: 10.2165/00003088-198713030-00002.
8
Gout induced by L-dopa and decarboxylase inhibitors.左旋多巴和脱羧酶抑制剂诱发的痛风。
Postgrad Med J. 1976 Apr;52(606):232-3. doi: 10.1136/pgmj.52.606.232.
9
Assessment of cerebrospinal fluid levels of dopamine metabolites by gas chromatography.通过气相色谱法评估脑脊液中多巴胺代谢物的水平。
Psychopharmacologia. 1975 Apr 30;42(1):57-6. doi: 10.1007/BF00428826.
10
Levodopa and decarboxylase inhibitors: a review of their clinical pharmacology and use in the treatment of parkinsonism.左旋多巴与脱羧酶抑制剂：其临床药理学及在帕金森病治疗中的应用综述
Drugs. 1976;11(5):329-77. doi: 10.2165/00003495-197611050-00001.