Devlin J G, Maguire O, Parameswaran V, Blake P J
Postgrad Med J. 1979;55 Suppl 2:14-8.
A study on humoral and cellular immune response to monocomponent (MC) insulin is reported. Humoral insulin antibody did not reach detectable levels in 80% of patients studied. Two out of six patients in whom a detectable antibody response was found had bovine species specific antibody suggesting some contamination of the insulin preparation used. No evidence for lymphocyte transformation with MC insulin was observed in the patients treated. B component resulted in transformation in patients treated with non-MC insulins. Zinc acted as a stimulant to lymphocyte transformation in the control group. The significance of the observations is discussed.
本文报道了一项关于对单组分（MC）胰岛素的体液和细胞免疫反应的研究。在80%的研究患者中，体液胰岛素抗体未达到可检测水平。在发现有可检测抗体反应的6名患者中，有2名患者产生了牛种特异性抗体，提示所使用的胰岛素制剂存在一定污染。在接受治疗的患者中，未观察到MC胰岛素诱导淋巴细胞转化的证据。B组分可使接受非MC胰岛素治疗的患者发生淋巴细胞转化。锌在对照组中可作为淋巴细胞转化的刺激物。文中讨论了这些观察结果的意义。
