家兔肾上腺去髓质化及外周注射6-羟基多巴胺：对体重、一般活动及心血管反应性的影响

Adrenal demedullation and peripheral 6-OHDA administration in the rabbit: effects on body weight, general activity and cardiovascular responsivity.

作者信息

Joseph J, Boggan W, Powell D A

出版信息

Pharmacol Biochem Behav. 1979 Jun;10(6):875-81. doi: 10.1016/0091-3057(79)90061-3.

Abstract

Two experiments were undertaken to determine the effects of systemic 6-hydroxydopamine (6-OHDA) administration and adrenal enucleation on body weight, brain and heart norepinephrine, general activity, and cardiovascular responsivity in the rabbit. 6-Hydroxydopamine produced long lasting, dose related decreases in baseline blood pressure (BP) and in pressor responses following electric shock. Partial reversal of the BP changes was observed in nonenucleated animals tested 20 days after 6-OHDA administration but not in enucleated animals tested 5, 10 or 20 days post-injection or in control animals tested 5, 10 or 15 days after vehicle injection. Although 6-OHDA administration produced transient weight loss and activity decrements, no long term weight or activity changes were observed.

摘要

进行了两项实验，以确定全身性给予6-羟基多巴胺（6-OHDA）和摘除肾上腺对兔子体重、脑和心脏去甲肾上腺素、一般活动以及心血管反应性的影响。6-羟基多巴胺使基线血压（BP）以及电击后的升压反应出现与剂量相关的长期降低。在给予6-OHDA后20天进行测试的未摘除肾上腺的动物中，观察到血压变化有部分逆转，但在注射后5、10或20天进行测试的摘除肾上腺的动物中，以及在注射赋形剂后5、10或15天进行测试的对照动物中均未观察到这种逆转。尽管给予6-OHDA会导致短暂的体重减轻和活动减少，但未观察到长期的体重或活动变化。