Vesey C J, Cole P V, Linnell J C, Wilson J
Br Med J. 1974 Apr 20;2(5911):140-2. doi: 10.1136/bmj.2.5911.140.
The infusion of sodium nitroprusside during surgical operations produced plasma levels of cyanide of up to four times the control value. Plasma thiocyanate showed little change except during prolonged infusion of the drug, but total plasma B(12) tended to fall, as did methylcobalamin. Other cobalamins showed little change after nitroprusside infusion for short periods. During longer infusions the ratio of methylcobalamin to adenosyl + hydroxocobalamin fell and cyanocobalamin concentrations were high.
手术过程中输注硝普钠使血浆氰化物水平高达对照值的四倍。除了长时间输注该药物期间，血浆硫氰酸盐变化不大，但血浆总钴胺素（B₁₂）以及甲钴胺均有下降趋势。短时间输注硝普钠后，其他钴胺素变化不大。长时间输注期间，甲钴胺与腺苷钴胺 + 羟钴胺的比值下降，氰钴胺浓度升高。
