Palmblad J, Petrini B, Wasserman J, Akerstedt T
Psychosom Med. 1979 Jun;41(4):273-8. doi: 10.1097/00006842-197906000-00001.
The possible influence of 48 hr of sleep deprivation on in vitro DNA synthesis of blood lymphocytes and on the adhesiveness and intracellular, stainable activity of alkaline phosphatase in blood granulocytes was studied in twelve young male volunteers. Following the sleep deprivation, all 12 subjects showed marked reductions of DNA synthesis after stimulation with phytohemagglutinin. Pre-exposure levels were regained 5 days after terminating the vigil. No changes were noted in granulocyte adherence or alkaline phosphatase activity. The results suggest that sleep deprivation may decrease cell-mediated immune reactions and thereby impair some aspects of host defense.
在12名年轻男性志愿者中研究了48小时睡眠剥夺对血液淋巴细胞体外DNA合成以及血液粒细胞碱性磷酸酶粘附性和细胞内可染色活性的可能影响。睡眠剥夺后，所有12名受试者在用植物血凝素刺激后DNA合成均显著降低。在结束通宵不睡后5天恢复到暴露前水平。粒细胞粘附性或碱性磷酸酶活性未发现变化。结果表明，睡眠剥夺可能会降低细胞介导的免疫反应，从而损害宿主防御的某些方面。
