暴露于A组链球菌细胞壁物质的巨噬细胞中细胞酶水平的变化及溶酶体酸性水解酶的细胞外释放。
Changes in cellular enzyme levels and extracellular release of lysosomal acid hydrolases in macrophages exposed to group A streptococcal cell wall substance.
作者信息
Davies P, Page R C, Allison A C
出版信息
J Exp Med. 1974 May 1;139(5):1262-82. doi: 10.1084/jem.139.5.1262.
Abstract
Mouse peritoneal macrophages exposed to type-specific polysaccharide and peptidoglycan (PPG) from group A streptococci undergo marked morphologic and biochemical changes. The cells show increases in size and an increased number of lysosomes as demonstrated by vital staining with acridine orange. There are significant elevations in the levels of both lysosomal and nonlysosomal enzymes. Higher doses of PPG cause selective release of the hydrolases into the extracellular environment with no detectable loss of cell viability. The in vitro phenomena may be relevant to understanding the role of macrophages in chronic inflammation.
摘要
暴露于A组链球菌的型特异性多糖和肽聚糖（PPG）的小鼠腹膜巨噬细胞会发生显著的形态和生化变化。通过吖啶橙活体染色显示，细胞体积增大，溶酶体数量增加。溶酶体酶和非溶酶体酶的水平均显著升高。高剂量的PPG会导致水解酶选择性释放到细胞外环境中，而细胞活力没有可检测到的损失。这些体外现象可能与理解巨噬细胞在慢性炎症中的作用有关。
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