生物合成途径的演变：免疫学方法
Evolution of biosynthetic pathways: immunological approach.
作者信息
Truffa-Bachi P, Guiso N, Cohen G N, Theze J, Burr B
出版信息
Proc Natl Acad Sci U S A. 1975 Apr;72(4):1268-71. doi: 10.1073/pnas.72.4.1268.
Abstract
Through the use of specific immunoadsorbent columns, it is shown that Escherichia coli aspartokinase I-homoserine dehydrogenase I, aspartokinase II-homoserine dehydrogenase II, aspartokinase III, and homoserine kinase, enzymes involved in the same complex biosynthetic pathway, share antigenic determinants. This raises the question of a common origin for the four cibtenoirart kinases. (Aspartate kinase or ATP:L aspartate 4-phosphotransferase, EC 2.7.2.4; homoserine dehydrogenase or Lhomoserine:NADP oxidoreductase, EC 1.1.1.3; homoserine kinase or ATP:L-homoserine O-phosphotransferase, EC 2.7.1.39.)
摘要
通过使用特定的免疫吸附柱表明，参与同一复杂生物合成途径的酶，即大肠杆菌天冬氨酸激酶I-高丝氨酸脱氢酶I、天冬氨酸激酶II-高丝氨酸脱氢酶II、天冬氨酸激酶III和高丝氨酸激酶，具有共同的抗原决定簇。这就引出了这四种激酶共同起源的问题。（天冬氨酸激酶或ATP：L-天冬氨酸4-磷酸转移酶，EC 2.7.2.4；高丝氨酸脱氢酶或L-高丝氨酸：NADP氧化还原酶，EC 1.1.1.3；高丝氨酸激酶或ATP：L-高丝氨酸O-磷酸转移酶，EC 2.7.1.39。）
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