Singh H M, Baker J T
Thorax. 1974 Jan;29(1):68-74. doi: 10.1136/thx.29.1.68.
. , , 68-74. . A study was made into the factors influencing the onset of jaundice in 102 patients undergoing valve replacement during cardiopulmonary bypass. Postoperative jaundice appeared to be correlated with double valve replacement, the co-existence of an uncorrected valvular lesion, length of perfusion and myocardial ischaemia times, and also the age of the patient. Factors appearing not to be correlated with the onset of jaundice included preoperative pulmonary artery pressure, cardiac index, parameters of preoperative renal and hepatic function, and the amount of blood used during bypass. The biochemical features of the jaundice seemed to follow a pattern not previously recognized in this context, with sometimes considerably raised bilirubin levels in association with virtually normal levels of transaminases and alkaline phosphatase.
对102例在体外循环下行瓣膜置换术患者黄疸发生的影响因素进行了研究。术后黄疸似乎与双瓣膜置换、未纠正的瓣膜病变并存、灌注时间和心肌缺血时间以及患者年龄有关。似乎与黄疸发生无关的因素包括术前肺动脉压、心脏指数、术前肾功能和肝功能参数以及体外循环期间的用血量。黄疸的生化特征似乎呈现出一种在此情况下以前未被认识到的模式，有时胆红素水平大幅升高，而转氨酶和碱性磷酸酶水平实际上正常。
