二碘羟基苯甲酸丁酯对垂体 - 甲状腺相互作用的影响。

Effect of butyldiiodohydroxybenzoate on pituitary-thyroid interplay.

作者信息

Iwasa Y, Tsukui T, Kanno Y, Koizumi Y, Kojima A, Yamada T

出版信息

Proc Soc Exp Biol Med. 1975 Apr;148(4):1167-72. doi: 10.3181/00379727-148-38710.

Abstract

The effect of BHDB, an analogue of thyroxine, on the pituitary-thyroid system was studied in the rat. BHDB produced low plasma T4 and T3 concentrations similar to those produced by methimazole, but failed to elevate plasma TSH and to produce goiter because of displacement of T4 from the binding protein. Low plasma thyroid hormone concentrations were due to an increase of fecal loss of thyroid hormones. By releasing excess iodide, BHDB blocked the development of goiter produced by methimazole.

摘要

研究了甲状腺素类似物BHDB对大鼠垂体-甲状腺系统的作用。BHDB使血浆T4和T3浓度降低，与甲巯咪唑产生的情况相似，但由于T4从结合蛋白上被置换，未能使血浆促甲状腺激素升高，也未引起甲状腺肿。血浆甲状腺激素浓度降低是由于甲状腺激素粪便排出量增加所致。通过释放过量碘化物，BHDB阻止了甲巯咪唑所致甲状腺肿的发展。