Montilla P, Muñoz M, Palacios J L
Rev Esp Fisiol. 1979 Jun;35(2):163-8.
In ovariectomized rats carrying an estradiol sylastic implant the effect of the intraventricular administration of the serotonin neurotoxin 5,6-dihydroxytryptamine and of the norepinephrine neurotoxin 6-hydroxydopamine on the circadian secretion of the luteinizing hormone (LH) was studied. The decrease of 5-HT after injection of 5,6-dihydroxytryptamine reduced the a.m. and p.m. values and suppressed the phasic rhythm of LH. The diminution of noradrenaline after administration of 6-hydroxydopamine increased the a.m. and did not alter the p.m. values, resulting in a partial abolition of the rhythm.
在携带雌二醇硅橡胶植入物的去卵巢大鼠中,研究了脑室内注射血清素神经毒素5,6 - 二羟基色胺和去甲肾上腺素神经毒素6 - 羟基多巴胺对促黄体生成素(LH)昼夜分泌的影响。注射5,6 - 二羟基色胺后5 - HT的减少降低了上午和下午的值,并抑制了LH的相位节律。给予6 - 羟基多巴胺后去甲肾上腺素的减少增加了上午的值,而下午的值没有改变,导致节律部分消失。