Michel D, Tommasi M, Rousset H, Bady B, Schott B
Rev Neurol (Paris). 1979 Jan;135(1):3-14.
Two cases of mainly interstitial myositis with epitheloid and giant cells are reported. In the first case, the late amyotrophic-type paralysis of the two girdles, of the clinical myositis type, was associated with severe myocardial damage, the atrioventricular conduction disorder requiring a pace-maker. This observation would appear to be a true polymyositis of the collagen diseases, in view of the associated skin affection, death occurring within a year, a large increase in serum muscle enzymes and urine creatine, the existence of a rheumatoid factor and striated muscle antibodies, and a large increase in M and G immunoglobulins. In the 2nd case, the amyotrophic affection of the pelvic girdle was associated with progressive blindness, diabetes insipidus, and anterior pituitary insufficiency. Death occurred after two years and autopsy showed a suprasellar dysgerminoma (ectopic pinealoma) without any visceral localization of sarcoidosis. The authors discuss the concept of granulomatous polymyositis, autonomous with respect to the sarcoidosis, and sometimes symptomatic of an inflammatory connective tissue condition or a malignant tumor.
报告了两例主要为间质性肌炎伴上皮样细胞和巨细胞的病例。第一例为临床肌炎型的双侧晚期肌萎缩型麻痹，伴有严重心肌损害，房室传导障碍需安装起搏器。鉴于存在相关皮肤病变、一年内死亡、血清肌酶和尿肌酸大幅升高、类风湿因子和横纹肌抗体以及M和G免疫球蛋白大幅升高，该病例似乎是胶原病的真正多发性肌炎。第二例为骨盆带肌萎缩性病变，伴有进行性失明、尿崩症和垂体前叶功能不全。两年后死亡，尸检显示鞍上生殖细胞瘤（异位松果体瘤），无任何结节病的内脏定位。作者讨论了肉芽肿性多肌炎的概念，它相对于结节病是独立的，有时是炎症性结缔组织病或恶性肿瘤的症状。
