Refsum S, Refsum S B, Bjørnland G
Scand J Urol Nephrol. 1979;13(2):207-9. doi: 10.3109/00365597909181179.
A case of bladder papilloma in a 12-year-old boy with Cushing's syndrome was reported by us in 1975. A walnut-sized papilloma was removed by transvesical extirpation, and bilateral adrenalectomy was performed. Two years later he was reoperated because of recurrent Cushing syndrome, and at the same time he had a recurrence of multiple bladder papillomas. Since removal of residual adrenocortical tissue and hormone substitution therapy his Cushing appearance has disappeared completely. The recurrent papillomas were removed by transurethral electrocoagulation and control cystoscopies have shown no sign tumour recurrence. We suggest a possible neoplastic effect of some tryptophan metabolites(s) in combination with immunosuppression as the cause of the bladder papillomas.
1975年我们报道了一例12岁患库欣综合征的男孩患有膀胱乳头状瘤的病例。经膀胱切除术切除了一个核桃大小的乳头状瘤，并进行了双侧肾上腺切除术。两年后，由于库欣综合征复发他再次接受手术，同时他的多发性膀胱乳头状瘤也复发了。自从切除残留的肾上腺皮质组织并进行激素替代治疗后，他的库欣面容已完全消失。复发性乳头状瘤通过经尿道电凝术切除，多次膀胱镜检查未发现肿瘤复发迹象。我们认为某些色氨酸代谢产物与免疫抑制相结合可能具有致瘤作用，这是膀胱乳头状瘤的病因。
