Sinclair G R, Lupu A N, de Kernion J B
Urology. 1975 May;5(5):665-8. doi: 10.1016/0090-4295(75)90126-0.
Eleven patients with terminal metastatic prostatic carcinoma were selected for a pilot study to evaluate how effective diethylstilbestrol diphosphate (Stilphostrol) and cylcophosphamide (Cytoxan) are in this disease. Six of 7 patients had a good response when treated with diethylstilbestrol diphosphate. The mean duration of response was 6.4 months. All 6 patients given cyclophosphamide had marked relief of pain and increased mobility. Of these, 3 died twelve, sixteen, and nineteen weeks, respectively, following initiation of therapy while still benefiting from pain relief. The mean duration of response was 14.8 weeks.
选择11例晚期转移性前列腺癌患者进行一项初步研究，以评估二磷酸己烯雌酚（己烯雌酚二磷酸酯）和环磷酰胺（癌得星）对此病的疗效。7例患者中有6例在接受二磷酸己烯雌酚治疗时有良好反应。平均反应持续时间为6.4个月。所有6例接受环磷酰胺治疗的患者疼痛明显缓解，活动能力增强。其中3例在开始治疗后分别于12周、16周和19周死亡，但仍从疼痛缓解中获益。平均反应持续时间为14.8周。
