Nachtsheim D A, McPherson R A, Pollen J J, Schmidt J D
Prostate. 1980;1(1):105-9. doi: 10.1002/pros.2990010114.
Transient thrombocytopenia was noted to occur in ten of 13 patients with advanced carcinoma of the prostate undergoing intravenous diethylstilbestrol diphosphate therapy. This was not associated with abnormalities of the initial platelet count or other parameters of the hemogram. There was no evidence of disseminated intravascular coagulation in these patients. No serious bleeding episodes occurred secondary to the thrombocytopenia. Following diethylstilbestrol diphosphate infusion, platelet counts generally returned to pretreatment levels. While the mechanism of action of the thrombocytopenia is unclear, we hypothesize a transient bone marrow toxicity as the cause of this phenomenon.
在13例接受静脉注射己烯雌酚二磷酸酯治疗的晚期前列腺癌患者中，有10例出现了短暂性血小板减少。这与初始血小板计数或血常规的其他参数异常无关。这些患者没有弥散性血管内凝血的证据。血小板减少未继发严重出血事件。己烯雌酚二磷酸酯输注后，血小板计数通常恢复到治疗前水平。虽然血小板减少的作用机制尚不清楚，但我们推测这种现象的原因是短暂性骨髓毒性。
