Charpin D, Orehek J, Velardocchio J M
Thorax. 1979 Apr;34(2):259-61. doi: 10.1136/thx.34.2.259.
In 12 asthmatic patients with mild airway obstruction we have measured the effect on specific airway resistance (sRaw) of inhaling the smoke of one Datura stramonium cigarette. In 11 patients sRaw decreased substantially after the cigarette, the mean maximal decrease being 40% at the 30th minute. In seven patients the subsequent inhalation of 200 micrograms salbutamol caused no further decrease in sRaw. In the remaining four patients salbutamol induced a larger decrease in sRaw than the cigarette smoke. The inhalation, however, of a synthetic anticholinergic agent (SCH 1000, 600 micrograms) proved as effective as salbutamol in these patients. In one patient the cigarette smoke and SCH 1000 produced only a negligible amount of bronchodilatation whereas the bronchial obstruction was reversible with salbutamol. Minor side effects were observed in six patients after the cigarette.
我们对12例轻度气道阻塞的哮喘患者吸入一支曼陀罗香烟烟雾后对特异性气道阻力（sRaw）的影响进行了测量。11例患者在吸完香烟后sRaw显著下降，第30分钟时平均最大降幅为40%。7例患者随后吸入200微克沙丁胺醇后sRaw未进一步下降。其余4例患者中，沙丁胺醇引起的sRaw下降幅度大于香烟烟雾。然而，吸入一种合成抗胆碱能药物（SCH 1000，600微克）在这些患者中被证明与沙丁胺醇一样有效。1例患者吸入香烟烟雾和SCH 1000后仅产生了可忽略不计的支气管扩张，而支气管阻塞可用沙丁胺醇逆转。6例患者吸完香烟后出现了轻微的副作用。
