细菌和病毒感染与哮喘加重的关系。
Relationship of bacterial and viral infections to exacerbations of asthma.
作者信息
Clarke C W
出版信息
Thorax. 1979 Jun;34(3):344-7. doi: 10.1136/thx.34.3.344.
Abstract
Fifty-one asthmatic patients were followed for up to 18 months. During this time 111 exacerbations of wheeze were recorded. Involvement by pathogenic respiratory bacteria and viruses was looked for directly by culture and indirectly by antibody studies. Proof of infection was found in only 12 (10.8%) of the 111 exacerbations. Only eight patients provided sputum samples. Potential bacterial pathogens were found in four. Viruses were isolated in four of 27 exacerbation specimens; significant rises in specific viral antibody titres occurred in three. Six patients developed precipitating antibody to respiratory bacteria over the study but only one in relation to an exacerbation. The study therefore indicated that the great majority of exacerbations of asthma in these patients were not due to respiratory tract infection.
摘要
51名哮喘患者被随访了长达18个月。在此期间，记录到111次喘息加重发作。通过培养直接寻找致病性呼吸道细菌和病毒的参与情况，并通过抗体研究间接寻找。在111次加重发作中，仅12次（10.8%）发现感染证据。只有8名患者提供了痰标本。在4份痰标本中发现了潜在的细菌病原体。在27份加重发作标本中有4份分离出病毒；3份标本中特定病毒抗体滴度显著升高。在研究过程中，6名患者产生了针对呼吸道细菌的沉淀抗体，但只有1名患者的抗体产生与一次加重发作有关。因此，该研究表明，这些患者中绝大多数哮喘加重发作并非由呼吸道感染所致。
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