Horn M E, Yealland S J
Arch Dis Child. 1974 Jul;49(7):516-9. doi: 10.1136/adc.49.7.516.
This study was undertaken in a primary school to determine how frequently viruses, and pathogenic bacteria could be isolated from children in whom there was no evidence of acute respiratory infection. The clinical status was firmly established before the virological and bacteriological results were recorded. Respiratory illness was found during 79 out of 224 interviews (35%). Specimens were taken at 112 of these interviews and children were re-examined 6 days later to ensure that no symptoms had developed during the intervening period. Viruses were isolated from 2 out of 65 (3%) of the investigations performed in asymptomatic children, compared with 11 out of 47 (23%) in those who had episodes of mild respiratory illnesses. and were more commonly isolated in the 47 children with symptoms than in those without. There was a close correlation between the virological findings of this study and those in children attending a nearby general practice, where the isolation rate in episodes of respiratory illness was 23% during the same period.
本研究在一所小学开展，以确定从无急性呼吸道感染证据的儿童中分离出病毒和致病菌的频率。在记录病毒学和细菌学结果之前，已明确确定临床状况。在224次访谈中有79次（35%）发现有呼吸道疾病。在其中112次访谈时采集了标本，6天后对儿童进行复查，以确保在此期间未出现任何症状。在无症状儿童进行的65项调查中有2项（3%）分离出病毒，而在有轻度呼吸道疾病发作的儿童中，47项中有11项（23%）分离出病毒。在有症状的47名儿童中比在无症状儿童中更常分离出病毒。本研究的病毒学结果与附近一家普通诊所儿童的结果密切相关，同期该诊所呼吸道疾病发作时的分离率为23%。
