Ikeda Y, Kikuchi M, Toyama K, Watanabe K, Ando Y
Thromb Haemost. 1979 Jun 30;41(4):779-86.
The effects of phospholipids on calcium uptake by human platelets were investigated utilizing 45CaCl2. Among the phospholipids tested, cardiolipin and phosphatidic acid exerted a significant increase of calcium uptake by platelets. Calcium uptake was dependent upon cardiolipin concentration and incubation time. These phospholipids enhanced platelet aggregation induced by ADP (2 microM) or epinephrine (0.5 microgram/ml). Cardiolipin caused the significant release of serotonin from platelets in the absence of externally added calcium in the medium. These results may suggest that phospholipids activate platelets through their ionophoretic activities.
利用45CaCl2研究了磷脂对人血小板摄取钙的影响。在所测试的磷脂中，心磷脂和磷脂酸使血小板摄取钙的量显著增加。钙摄取量取决于心磷脂浓度和孵育时间。这些磷脂增强了由ADP（2微摩尔）或肾上腺素（0.5微克/毫升）诱导的血小板聚集。在心磷脂存在且培养基中无外源添加钙的情况下，心磷脂会导致血小板中5-羟色胺的显著释放。这些结果可能表明磷脂通过其离子载体活性激活血小板。
