Bruce A
J Lipid Res. 1974 Mar;15(2):109-13.
The fatty acids in cardiolipin, choline phosphoglyceride, ethanolamine phosphoglyceride, inositol phosphoglyceride, and serine phosphoglyceride in the human gastrocnemius muscle were studied for changes between early fetal age to middle age. In cardiolipin, choline phosphoglyceride, and ethanolamine phosphoglyceride, the relative total amount of the linoleic acid series increased considerably during the prenatal period and reached maximum values during the first year of life. In inositol phosphoglyceride and serine phosphoglyceride, only slight changes in the sum of fatty acids of the linoleic acid series were found. An increase in the concentration of fatty acids of the linolenic acid series was found in ethanolamine phosphoglyceride and serine phosphoglyceride, while only minor amounts of these fatty acids were present in choline phosphoglyceride and inositol phosphoglyceride and not at all in cardiolipin. During the period studied, the amount of plasmalogen in ethanolamine phosphoglyceride decreased slightly during the first year of life and then remained at 40%. The amount of plasmalogen increased in choline phosphoglyceride from 8% at the middle of the gestational period to 15% 1 yr after birth. The individual phospholipids were found to have characteristic fatty acid patterns.
对人腓肠肌中的心磷脂、胆碱磷酸甘油酯、乙醇胺磷酸甘油酯、肌醇磷酸甘油酯和丝氨酸磷酸甘油酯中的脂肪酸，研究了从胎儿早期到中年期间的变化。在心磷脂、胆碱磷酸甘油酯和乙醇胺磷酸甘油酯中，亚油酸系列的相对总量在产前期间大幅增加，并在生命的第一年达到最大值。在肌醇磷酸甘油酯和丝氨酸磷酸甘油酯中，仅发现亚油酸系列脂肪酸总和有轻微变化。在乙醇胺磷酸甘油酯和丝氨酸磷酸甘油酯中发现亚麻酸系列脂肪酸浓度增加，而在胆碱磷酸甘油酯和肌醇磷酸甘油酯中仅存在少量这些脂肪酸，在心磷脂中则完全不存在。在所研究的期间，乙醇胺磷酸甘油酯中的缩醛磷脂量在生命的第一年略有下降，然后保持在40%。胆碱磷酸甘油酯中的缩醛磷脂量从孕期中期的8%增加到出生后1年的15%。发现各个磷脂具有特征性的脂肪酸模式。
