Nishioka K
Tohoku J Exp Med. 1979 Aug;128(4):401-2.
The effect of a non-narcotic analgesic, tramadol, 5 mg/kg i.v. on cardiac contractility was studied in intact dog. The maximal intrinsic velocity of contraction of the ventricle, dP/dt/K P at P=O(Vmax) which is a most sensitive and reliable index of cardiac contractility, was decreased significantly 5 and 10 min after the injection, suggesting that the drug is a mild myocardial depressant at this dose and by this route.
在完整的犬身上研究了非麻醉性镇痛药曲马多静脉注射5mg/kg对心脏收缩力的影响。心室收缩的最大内在速度，即P = 0时的dP/dt/K P（Vmax），它是心脏收缩力最敏感和可靠的指标，在注射后5分钟和10分钟时显著降低，这表明该药物在这个剂量和通过这种给药途径时是一种轻度的心肌抑制剂。
