Seitz W, Lübbe N, Fritz K, Sybrecht G, Kirchner E
Anaesthesist. 1985 May;34(5):241-6.
The respiratory depressant effects of 1.0 and 1.5 mg/kg of tramadol were studied in 14 healthy young persons by determining the CO2 response (Read's method) and the mouth occlusion pressure (Whitelaw's method) before and 10, 30 and 60 min after administration of the drug. The decrease in minute volume VE (PACO2 = 55 mmHg), dependent on dose, ranged between 11,2 and 17,8%. The mean ventilatory response to CO2 decreased after administration of 1.0 and 1.5 mg/kg of tramadol by 15.4 and 25.4% respectively of the normal value. In the same patients, the mouth occlusion pressure responses decreased by 16.1 and 25.6% respectively. There were no significant changes in mean inspiratory flow rate (determined from tidal volume and averaged time of inspiration). These findings demonstrate that tramadol, in contrast to morphine, produces less depression of the ventilatory responses to CO2 in healthy subjects.
通过在给药前以及给药后10、30和60分钟测定二氧化碳反应（里德法）和口腔闭合压（惠特洛法），对14名健康年轻人研究了1.0毫克/千克和1.5毫克/千克曲马多的呼吸抑制作用。分钟通气量VE（肺泡二氧化碳分压=55毫米汞柱）的降低取决于剂量，范围在11.2%至17.8%之间。给予1.0毫克/千克和1.5毫克/千克曲马多后，对二氧化碳的平均通气反应分别降低了正常值的15.4%和25.4%。在同一批患者中，口腔闭合压反应分别降低了16.1%和25.6%。平均吸气流量（由潮气量和平均吸气时间确定）无显著变化。这些发现表明，与吗啡不同，曲马多对健康受试者对二氧化碳的通气反应产生的抑制作用较小。
