Abramian D S, Ignatova T N, Glebova O K
Tsitologiia. 1979 Jul;21(7):842-8.
The stability of the 8-azaguanine resistance marker during the number of cell generations has been analyzed for 63 clones of Chinese hamster cells. The resistant clones analyzed were spontaneous or induced after the treatment of parent cells by 5-BUdR, EMS, or histone H1. The clones have revealed different levels of AG-resistance as well as different ability to maintain the above level, under the cultivation in the drug-free medium. Subclones, isolated from the unstable clone, were found to be different in both the resistance level and the stability of resistant state.
对63个中国仓鼠细胞克隆在细胞传代过程中8-氮杂鸟嘌呤抗性标记的稳定性进行了分析。所分析的抗性克隆为自发产生的，或亲本细胞经5-溴脱氧尿苷（5-BUdR）、甲基磺酸乙酯（EMS）或组蛋白H1处理后诱导产生的。这些克隆在无药物培养基培养条件下，表现出不同水平的AG抗性以及维持上述抗性水平的不同能力。从不稳定克隆中分离出的亚克隆，在抗性水平和抗性状态的稳定性方面均存在差异。
