纳洛酮对清醒受试者吗啡作用的逆转程度及持续时间。
Degree and duration of reversal by naloxone of effects of morphine in conscious subjects.
作者信息
Evans J M, Hogg M I, Lunn J N, Rosen M
出版信息
Br Med J. 1974 Jun 15;2(5919):589-91. doi: 10.1136/bmj.2.5919.589.
Abstract
The effects of intravenous naloxone on several of the actions of intravenous morphine (mean dose 30 mg/70 kg) were studied in six volunteer subjects. Naloxone produced a well defined reversal of the respiratory depression, analgesia, and miotic and subjective effects of the morphine. The agonist action of morphine outlasted the antagonist action of a single dose of naloxone. The effect of repeated doses of naloxone was also short-lived, but continuous infusions were effective in maintaining reversal.
摘要
在六名志愿者身上研究了静脉注射纳洛酮对静脉注射吗啡（平均剂量30毫克/70千克）多种作用的影响。纳洛酮使吗啡所致的呼吸抑制、镇痛、缩瞳及主观效应得到明确的逆转。吗啡的激动剂作用持续时间超过单次剂量纳洛酮的拮抗剂作用。重复给予纳洛酮的效果也是短暂的，但持续输注在维持逆转方面是有效的。
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