Levy L, Ullmann N M
Am Rev Respir Dis. 1975 May;111(5):651-5. doi: 10.1164/arrd.1975.111.5.651.
Multiplication of Mycobacterium leprae in the mouse footpad was inhibited when mice were fed, mixed in their diet, 0.05 per cent methimazole, 0.066 per cent USP thyroid powder, methimazole plus thyroid powder, 0.15 per cent 5-n-heptyl-2-thioxo-4-thiazolidinone, 0.1 per cent propylthiouracil, and 0.1 per cent thambutosine for 154 days, beginning on the day of inoculation. All of the treatment regimens, except for the 2 containing thyroid powder, decreased the plasma concentrations of thyroxine and protein-bound iodine. It is suggested that the 2 antithyroid drugs, methiomazole and propylthiouracil, and the 2 antimicrobial agents, heptylthioxothiazolidinone and thiambutosine, all of which possess structural features in common, may exert the antithyroid and antimicrobial effects through a common mechanisms.
从接种日起，给小鼠喂食混入其饮食中的0.05%甲巯咪唑、0.066%美国药典甲状腺粉、甲巯咪唑加甲状腺粉、0.15%5 -正庚基 - 2 -硫代 - 4 -噻唑烷酮、0.1%丙硫氧嘧啶和0.1%氨苯砜154天，麻风分枝杆菌在小鼠足垫中的繁殖受到抑制。除含甲状腺粉的两种治疗方案外，所有治疗方案均降低了甲状腺素和蛋白结合碘的血浆浓度。有人提出，两种抗甲状腺药物甲巯咪唑和丙硫氧嘧啶，以及两种抗菌剂庚基硫代噻唑烷酮和氨苯砜，它们都具有共同的结构特征，可能通过共同机制发挥抗甲状腺和抗菌作用。
