Eberlein T J, Carey L C
Ann Surg. 1974 Jun;179(6):836-41. doi: 10.1097/00000658-197406000-00003.
The high incidence of pulmonary embolism is well documented. At first suspicion of an embolism attack, adequate anticoagulant therapy was administered to 86% of the patients in this study. With failure of anticoagulants preoperatively, 30 patients received partial interruption of the IVC, 26 patients had their IVC ligated. Postoperatively, anticoagulants were administered to 64% of the patients who subsequently suffered recurrent attacks of embolism or new episodes of acute thrombophlebitis. These patients also had a substantial hazard of hemorrhage since 48% of the patients on heparin required transfusion. Postoperative mortality for the ligation group was associated with underlying conditions of the patients. These patients subjected to IVC plication had more deaths due to recurrence of pulmonary emboli and were demonstrated to have a substantially higher recurrence rate of pulmonary embolus. Reasons for this recurrence in both groups are discussed. Severe leg sequlae problems often associated with ligation were not encountered but were present in several patients subjected to plication.
肺栓塞的高发病率有充分的文献记载。在本研究中,一旦怀疑有栓塞发作,86%的患者接受了充分的抗凝治疗。术前抗凝治疗失败时,30例患者接受了下腔静脉部分阻断,26例患者进行了下腔静脉结扎。术后,64%随后发生栓塞复发或急性血栓性静脉炎新发作的患者接受了抗凝治疗。这些患者也有相当大的出血风险,因为48%接受肝素治疗的患者需要输血。结扎组的术后死亡率与患者的基础疾病有关。接受下腔静脉折叠术的这些患者因肺栓塞复发导致更多死亡,并且被证明肺栓塞复发率显著更高。讨论了两组复发的原因。未遇到通常与结扎相关的严重腿部后遗症问题,但在接受折叠术的几名患者中存在。